PPS: What Does It Mean And What Is Used For?

What is pentosan polysulfate sodium? It is the sodium salt of the semisynthetic heparin-like glycosaminoglycan. The mechanism of action of PPS is unknown. It may act as a protector to manage cell permeability by stopping irritating solutes from getting the cells coated with it.

PPS is administered orally. When it adheres to the urinary bladder wall, it prevents irritations from entering the bladder cells, as well as the progression or development of IC or interstitial cystitis. A complication of chemotherapies. The agent exhibits fibrinolytic or anticoagulant properties.

What does it use for?

The Pentosan polysulfate sodium is used for symptom relief, pain, or discomfort of interstitial cystitis or inflammation of the bladder. The medicine is prescribed by a doctor. The product is generally in capsule form.

Before using

The doctor will prescribe the medicine to use. The medicine is considered to use for the following conditions:

  • Pediatric. An appropriate study is performed on the age effects of PPS in children lower than 16 years old.
  • Allergies. Tell the doctor you have an allergic or unusual reaction to the medicine while using it for medication. You may also tell your health care professional if you have other types of allergies, such as on:
    • Foods
    • Dyes
    • Preservatives
    • Animals

For non-prescription products, you may read the label or package ingredients cautiously.

  • Geriatric. A study has been performed according to age to the effects of the drug on the geriatric population.
  • Breastfeeding. There are not enough studies on breastfeeding women. There are no adequate studies on breastfeeding women to determine infant risk when using the drug. Weigh the probable benefits against the potential risks before taking the medication while feeding the infant.
  • Drug interactions. Even though certain medicines must be used together, there are two different medicines used together even if an interaction occurs. In this case, the doctor may want to alter the dose or other precautions that may be necessary. When taking this medicine, your healthcare professional must know if you take any of the medicines aside from PPS.

Is PPS a steroid?

PPS is not prohibited. The drug is neither an anabolic steroid nor an opioid-based pain reliever. So, it is not considered a performance enhancer.


PPS was first developed by a German researcher for blood clot treatments. PPS in Australia is available only by prescription while in other countries it is not. It is under the brand name Elmiron. The drug works by passing through the kidneys into the urine, where it coats the inner walls of the bladder.

PPS prevents microorganisms attached to the bladder and causes possible infections. So, if you have any pain felt and you get the idea of taking PPS for treatment, consult your doctor and get a prescription for it.


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